Endocrine Abstracts

Introduction: Thyroid disease is associated with cardiovascular disease and many cardiovascular risk factors cluster within the metabolic syndrome. It could therefore be hypothesised that thyroid function is associated with the metabolic syndrome.Aim of the study: To investigate the relationship of thyroid function -in the euthyroid range- with serum lipid concentrations and with insulin resistance.Methods: 2703 adult inhabitants o...

Introduction: Thyroglobulin (Tg) measurement is the cornerstone in the follow-up of DTC. Sensitivity can be optimised by measuring recombinant TSH stimulated Tg (rhTSH-Tg). Higher sensitivity results in more Tg positive patients who need imaging and considerable patient burden. We assessed the impact of rhTSH-Tg measurement on health related quality of life (HRQOL).Methods: In 121 patients in follow-up for DTC, Tg during thyroid hormone suppression thera...

Introduction: Thyroid disease, both clinical and subclinical, is a common disorder. Various studies, however, differ in reported prevalences of abnormal thyroid function.Aim of the study: To investigate 1. the prevalence of abnormal thyroid function and anti-thyroidperoxidase antibodies (TPOab) in a random sample of the inhabitants of a middle-sized city in the Netherlands; 2. the relationship of the presence of TPOab with TSH concentration in the euthyr...

Introduction: A substantial proportion of pheochromocytomas (PCC) are detected during the work-up of an adrenal incidentaloma. Recently it has been suggested that in case of an adrenal incidentaloma with an unenhanced attenuation value <10 Hounsfield Units (HU) on CT imaging biochemical testing to rule out PCC is unnecessary. We aimed to determine the sensitivity of the 10 HU cut-off value to detect pheochromocytoma.Methods: Retrospective multicenter...

Background/Aim: Neuroendocrine tumors (NETs) are rare tumors arising from neuroendocrine cells throughout the body. Positron Emission Tomography (PET) scanning with 6-[18F]fluor-L-3,4-dihydroxyphenylalanine (18F-FDOPA) has been shown to be a valuable technique for the imaging of NETs. While the sensitivity has been assessed numerously, studies systematically describing false positive results, other than physiological variants, are lacking. Our aim was to systematica...

Background: Administration of α-adrenergic receptor antagonists is recommended before resection of a pheochromocytoma (PCC) in order to prevent perioperative cardiovascular complications. For this purpose either phenoxybenzamine (PXB) or doxazosin (DOX) is commonly prescribed. We conducted the first randomized controlled trial comparing the efficacy of PXB and DOX in controlling perioperative hemodynamics in patients undergoing PCC resection (ClinicalTrials.gov:NCT0137989...